So, what is the impacted hair follicle dog treatment? Therapy of affected hair follicles in dogs is usually with gentle cleansing of the affected region, application of warm compress to promote drainage, trimming or shaving of the surrounding hair to reduce irritation, antiseptic solution to prevent infection and in severe cases veterinary care where the vet may lance the follicle, prescribe antibiotics or recommend surgical ablation where the condition is recurrent or associated with cysts.