The most awaited yearly changes for CPT codes 2025 have finally been announced by AMA. There are 420 overall updates in the AMA CPT 2025 code set, including 270 new codes, 112 deletions, and 38 revisions. These changes reflect rapid advancements in various fields of medicine, particularly in proprietary lab analyses, which account for 37% of new codes, driven mainly by novel genetic testing. Additionally, Category III CPT codes, which represent emerging medical services, account for nearly a third of the new codes.