To apply for a work permit as a nurse in Canada, first, ensure you meet eligibility requirements, including education, work experience, language proficiency, and provincial nursing licensing. Secure a job offer from a Canadian employer, and your employer may need to obtain a Labour Market Impact Assessment (LMIA). Submit your work permit application online with supporting documents such as your job offer, proof of qualifications, and LMIA (if required). Wait for the processing decision, and upon approval, prepare for relocation and integration into Canada's healthcare system.