Boronic Acid Formula | Boronic Acid

In its simplest form, the boronic acid formula is RB(OH)2, where R represents an alkyl, aryl, or other organic group. The structural properties of boronic acid are critical for understanding its chemical behaviour and uses. Boronic acid contains an empty p orbital, which allows it to function as a Lewis acid by accepting an electron pair from a Lewis base. This property allows boronic acid to form stable complexes with Lewis bases, such as oxygen or nitrogen-containing molecules.

Furthermore, the presence of a hydroxyl group close to the boron atom promotes the formation of reversible covalent bonds with diols and other nucleophiles, known as boronate ester formation. This unusual reactivity has resulted in the creation of boronic acid-based sensors, probes, and molecular recognition agents for detecting and binding certain biomolecules and analytes.

Boronic acids and their derivatives have become popular in medicinal chemistry because of their ability to establish reversible covalent connections with biological targets such as enzymes and receptors. Boronic acid-containing chemicals are used to create proteasome inhibitors for cancer treatment, antiviral medicines, and enzyme inhibitors for diabetic management.
Boronic acid-functionalized polymers and surfaces have distinct features, such as self-healing, stimulus-responsive behaviour, and selective molecular recognition. These materials have uses in sensors, medication delivery systems, and separation technologies.